PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling

Volume: 9, Issue: 2
Published: Feb 7, 2018
Abstract
Cancer stem cells (CSCs) are involved in metastasis and resistance development, thus affecting anticancer therapy efficacy. The underlying pathways required for CSC maintenance and survival are not fully understood and only a limited number of treatment strategies to specifically target CSCs have been identified. To identify novel CSC targeting compounds, we here set-up an aldehyde dehydrogenase (ALDH)-based phenotypic screening system that...
Paper Details
Title
PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling
Published Date
Feb 7, 2018
Journal
Volume
9
Issue
2
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