Fluorescence anisotropy imaging in drug discovery
Abstract
Non-invasive measurement of drug-target engagement can provide critical insights in the molecular pharmacology of small molecule drugs. Fluorescence polarization/fluorescence anisotropy measurements are commonly employed in protein/cell screening assays. However, the expansion of such measurements to the in vivo setting has proven difficult until recently. With the advent of high-resolution fluorescence anisotropy microscopy it is now possible...
Paper Details
Title
Fluorescence anisotropy imaging in drug discovery
Published Date
Nov 1, 2019
Volume
151-152
Pages
262 - 288
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