Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery
Abstract
Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have many side effects, including cognitive impairment, tolerance, rebound insomnia upon discontinuation, car accidents/falls, abuse, and dependence liability. Consequently, the clinical use of off-label drugs and novel drugs that do not target the GABAergic system is increasing....
Paper Details
Title
Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery
Published Date
Feb 27, 2018
Journal
Volume
70
Issue
2
Pages
197 - 245
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