Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.
Abstract
Autophagy is a conserved eukaryotic process with metabolic, immune, and general homeostatic functions in mammalian cells. Mammalian autophagosomes fuse with lysosomes in a SNARE-driven process that includes syntaxin 17 (Stx17). How Stx17 translocates to autophagosomes is unknown. In this study, we show that the mechanism of Stx17 recruitment to autophagosomes in human cells entails the small guanosine triphosphatase IRGM. Stx17 directly...
Paper Details
Title
Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.
Published Date
Mar 5, 2018
Journal
Volume
217
Issue
3
Pages
997 - 1013
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Notes
History