Yeast surface display platform for rapid discovery of conformationally selective nanobodies

Volume: 25, Issue: 3, Pages: 289 - 296
Published: Feb 12, 2018
Abstract
Camelid single-domain antibody fragments (‘nanobodies’) provide the remarkable specificity of antibodies within a single 15-kDa immunoglobulin VHH domain. This unique feature has enabled applications ranging from use as biochemical tools to therapeutic agents. Nanobodies have emerged as especially useful tools in protein structural biology, facilitating studies of conformationally dynamic proteins such as G-protein-coupled receptors (GPCRs)....
Paper Details
Title
Yeast surface display platform for rapid discovery of conformationally selective nanobodies
Published Date
Feb 12, 2018
Volume
25
Issue
3
Pages
289 - 296
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