Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations

Biliary tract cancers (BTCs) are clinically and pathologically heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer understanding of their carcinogenesis, classification and treatment strategy. We performed large-scale genome sequencing analyses on BTCs to investigate their somatic and germline driver events and characterize their genomic landscape.We analyzed 412 BTC samples from Japanese and Italian populations,...