Efeito da dieta hiperlipídica e da tintura de Valeriana officinalis no modelo crônico de discinesia orofacial induzida por haloperidol em ratos

Published on Oct 30, 2006
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#1Abdulhakeem A. Al-Majed (KSU: King Saud University)H-Index: 22
#2Abdulaziz A. Al-Yahya (KSU: King Saud University)H-Index: 16
Last. Sumizah Qureshi (KSU: King Saud University)H-Index: 24
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Abstract Valerian is widely known for its use as a sedative and an anti-anxiety drug in the folk medicine. Literature reports suggested valerian to induce genotoxicity in vitro (ECV304 cells) by reactive oxygen species-mediated mechanism; however, there are no reports on its genotoxicity and/or the epigenetic mechanism in vivo. In view of the folkloric significance, it was found worthwhile to (1) determine the genotoxic effects of valerian in somatic and germ cells of mice and (2) investigate th...
23 CitationsSource
#1Caroline Wagner (UFSM: Universidade Federal de Santa Maria)H-Index: 15
#2Roselei Fachinetto (UFSM: Universidade Federal de Santa Maria)H-Index: 21
Last. João Rocha (UFSM: Universidade Federal de Santa Maria)H-Index: 82
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Abstract Reactive oxygen species have been demonstrated to be associated with a variety of diseases including neurodegenerative disorders. Flavonoid compounds have been investigated for their protective action against oxidative mechanisms in different in vivo and in vitro models, which seems to be linked to their antioxidant properties. In the present study, we examine the protective mechanism of quercitrin, a glycoside form of quercetin, against the production of TBARS induced by different agen...
120 CitationsSource
#1Marilise Escobar Burger (UFSM: Universidade Federal de Santa Maria)H-Index: 27
#2Roselei Fachinetto (UFSM: Universidade Federal de Santa Maria)H-Index: 21
Last. João Rocha (UFSM: Universidade Federal de Santa Maria)H-Index: 82
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Abstract Recently, we have described the beneficial effects of Diphenyl diselenide, an organochalcogen with glutathione peroxidase-like activity, on reserpine-induced orofacial dyskinesia in old rats. In this study, our aim was to examine the effects of diselenide on haloperidol-induced orofacial dyskinesia in rats. Male wistar rats received one single dose of Haloperidol decanoate (57 mg/kg/im) or control. After this dose, the animals received daily administration of diphenyl diselenide (1, 5 o...
54 CitationsSource
#1Roselei Fachinetto (UFSM: Universidade Federal de Santa Maria)H-Index: 21
#2Lucinéia A. Pivetta (UFSM: Universidade Federal de Santa Maria)H-Index: 5
Last. João Rocha (UFSM: Universidade Federal de Santa Maria)H-Index: 82
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Abstract Ethanol toxicity is affected by both environmental and inherited features. Since oxidative stress is an important molecular mechanism for ethanol-induced cellular damage, the concomitant exposure to ethanol and pro-oxidative or antioxidant compounds can alter its toxicity. Here, we investigate the effects of exposure to ethanol and/or diphenyl diselenide, an organochalcogen with antioxidant properties, on parameters related to oxidative stress (thiobarbituric acid reactive species—TBARS...
16 CitationsSource
#1David O. Kennedy (Northumbria University)H-Index: 49
#2Wendy Little (Northumbria University)H-Index: 2
Last. Andrew Scholey (Northumbria University)H-Index: 60
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Objective: Melissa officinalis (lemon balm) and Valeriana officinalis (valerian) have been used both traditionally and contemporaneously as mild sedatives, anxiolytics and hypnotics. Recent research has suggested that both may attenuate laboratory induced stress. As the two herbs are most often sold in combination with each other the current study assessed the anxiolytic properties of such a combination during laboratory-induced stress. Methods: In this double-blind, placebo-controlled, randomiz...
252 CitationsSource
#1Lucielli Savegnago (UFSM: Universidade Federal de Santa Maria)H-Index: 22
#2Cristina W. Nogueira (UFSM: Universidade Federal de Santa Maria)H-Index: 53
Last. João Rocha (UFSM: Universidade Federal de Santa Maria)H-Index: 82
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The degradation of nucleotides is catalyzed by the family of enzymes called nucleoside triphosphate diphosphohydrolases (NTPDases). The aim of this work was to demonstrate the presence of NTPDase in the rat gastric mucosa. The enzyme was found to hydrolyze ATP and ADP at an optimum pH of 8.0 in the presence of Mg2+ and Ca2+. The inhibitors ouabain (0.01–1 mM), N-ethylmaleimide (0.01–4 mM), levamisole (0.10–0.2 mM) and Ap5A (0.03 mM) had no effect on NTPDase 1 activity. Sodium azide (0.03–30 mM),...
11 CitationsSource
#1Rulian Ricardo Faria (UNIFESP: Federal University of São Paulo)H-Index: 3
#2Vanessa C. Abílio (UNIFESP: Federal University of São Paulo)H-Index: 29
Last. Roberto Frussa-Filho (UNIFESP: Federal University of São Paulo)H-Index: 37
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Oral dyskinesias are implicated in a series of neuropathologies and have been associated to an increase in oxidative stress. Several antioxidants, including vitamin E, decrease reserpine-induced oral dyskinesia (OD) in rodents and we have described a protective role of striatal catalase against the development of OD. The aim of this study was to verify the effects of vitamin C alone or in combination with vitamin E on reserpine-induced OD as well as to determine a possible role of catalase in th...
59 CitationsSource
#2Roselei Fachineto (UFSM: Universidade Federal de Santa Maria)H-Index: 1
Last. João Rocha (UFSM: Universidade Federal de Santa Maria)H-Index: 82
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Reserpine- and haloperidol-induced orofacial dyskinesia are putative animal models of tardive dyskinesia (TD) whose pathophysiology has been related to free radical generation and oxidative stress. In the present study, the authors induced orofacial dyskinesia by acute reserpine and subchronic haloperidol administration to rats. Reserpine injection (one dose of 1 mg/kg s.c.) every other day for 3 days caused a significant increase in vacuous chewing, tongue protrusion and duration of facial twit...
71 CitationsSource
#1N.P. Araujo (UNIFESP: Federal University of São Paulo)H-Index: 8
#2Vanessa C. Abílio (UNIFESP: Federal University of São Paulo)H-Index: 29
Last. Roberto Frussa-Filho (UNIFESP: Federal University of São Paulo)H-Index: 37
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Abstract Recently, we have described the antidyskinetic property of the GABA mimetic drug valproic acid on reserpine-induced oral dyskinesia, an animal model that has been related to tardive as well as acute dyskinesias, which are associated with important neuropathologies. The present study investigates the effects of different doses of the GABA mimetic anticonvulsant topiramate on the manifestation of reserpine-induced orofacial dyskinesia. Female EPM-M1 mice received two injections of control...
17 CitationsSource
Excitotoxicity elicited by overactivation of N-methyl-d-aspartate receptors is a well-known characteristic of quinolinic acid-induced neurotoxicity. However, since many experimental evidences suggest that the actions of quinolinic acid also involve reactive oxygen species formation and oxidative stress as major features of its pattern of toxicity, the use of antioxidants as experimental tools against the deleterious effects evoked by this neurotoxin becomes more relevant. In this work, we invest...
193 CitationsSource
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