Original paper

Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria

Volume: 44, Issue: 4, Pages: 484 - 499.e6
Published: Feb 1, 2018
Abstract
Mitochondrial quality control is essential to maintain cellular homeostasis and is achieved by removing damaged, ubiquitinated mitochondria via Parkin-mediated mitophagy. Here, we demonstrate that MYO6 (myosin VI), a unique myosin that moves toward the minus end of actin filaments, forms a complex with Parkin and is selectively recruited to damaged mitochondria via its ubiquitin-binding domain. This myosin motor initiates the assembly of F-actin...
Paper Details
Title
Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria
Published Date
Feb 1, 2018
Volume
44
Issue
4
Pages
484 - 499.e6
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