Autologous Hematopoietic Stem Cell Transplantation May be Highly Effective Treatment for Severe Stiff Person Syndrome

Stiff person syndrome (SPS) is a rare and disabling neurological disease characterized by progressive stiffness of skeletal muscles, rigidity and episodic painful muscle spasms, resulting in severely impaired volitional movements and ambulation in some patients (pts). Electromyography (EMG) typically shows continuous motor activity. 60% -80% of affected pts have autoantibodies against glutamic acid decarboxyloase (GAD), a key enzyme for...