TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease

Volume: 314, Issue: 5, Pages: H978 - H990
Published: May 1, 2018
Abstract
Chronic iron overload results in heart and liver diseases and is a common cause of morbidity and mortality in patients with genetic hemochromatosis and secondary iron overload. We investigated the role of tissue inhibitor of metalloproteinase 3 (TIMP3) in iron overload-mediated tissue injury by subjecting male mice lacking Timp3 ( Timp3 −/− ) and wild-type (WT) mice to 12 wk of chronic iron overload. Whereas WT mice with iron overload developed...
Paper Details
Title
TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease
Published Date
May 1, 2018
Volume
314
Issue
5
Pages
H978 - H990
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