Linaclotide in irritable bowel syndrome with constipation: A Phase 3 randomized trial in China and other regions

Background and Aim Linaclotide is a guanylate cyclase‐C agonist approved in multiple countries to treat irritable bowel syndrome with constipation (IBS‐C). China has unmet need for well‐tolerated therapy that is effective in treating both bowel and abdominal symptoms of IBS‐C. This trial evaluated linaclotide's efficacy and safety in IBS‐C patients in China and other regions. Methods This Phase 3, double‐blind trial randomized IBS‐C patients to...