Epidemiology

Internal medicine

Cancer registry

Pancreas

Surveillance, Epidemiology, and End Results

Gastroenterology

Cancer

Oncology

Carcinoma

Ampulla of Vater

Lymph node

Pancreaticoduodenectomy

Adenocarcinoma

Periampullary cancer

Adjuvant radiotherapy

Radiation therapy

Medicine

Clinical & Translational Oncology

Introduction This study set to examine relative survival of patients with periampullary cancers undergoing pancreaticoduodenectomy (PD). Methods Using the Surveillance, End Results and Epidemiology (SEER) database, this study identified 9877 patients with non-metastatic pancreatic adenocarcinoma who underwent PD between 2004 and 2013. Results Ampullary carcinomas have the best survival among periampullary malignancies. Lymph node ratio is a significant prognostic factor, even when stratified by tumour types. Patients receiving adjuvant radiotherapy following PD have superior survival than patients without radiotherapy (median 25 vs 20 months, p < 0.001), particularly ductal adenocarcinoma (HR: 0.74, CI95% 0.69–0.78; p < 0.001), cholangiocarcinoma (HR: 0.75, CI95% 0.59–0.97; p = 0.027), and ampullary carcinoma (HR: 0.79, CI95% 0.64–0.98; p = 0.029) with greatest survival benefit at 1-year postresection. Conclusion Future studies aiming to further define genetic signatures of individual periampullary cancers would allow a personalised therapeutic approach in improving survival.

Pancreaticoduodenectomy for periampullary tumours: a review article based on Surveillance, End Results and Epidemiology (SEER) database