The role of Nrf2 signaling in counteracting neurodegenerative diseases.
Abstract
The transcription factor Nrf2 (nuclear factor‐erythroid 2 p45‐related factor 2) functions at the interface of cellular redox and intermediary metabolism. Nrf2 target genes encode antioxidant enzymes, and proteins involved in xenobiotic detoxification, repair and removal of damaged proteins and organelles, inflammation, and mitochondrial bioenergetics. The function of Nrf2 is altered in many neurodegenerative disorders, such as Huntington's...
Paper Details
Title
The role of Nrf2 signaling in counteracting neurodegenerative diseases.
Published Date
Oct 1, 2018
Journal
Volume
285
Issue
19
Pages
3576 - 3590
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Notes
History