Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
Abstract
To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis clinical isolates from more than 30 countries. A GWAS approach within a mixed-regression framework was followed by a phylogenetics-based test for independent mutations. In addition to mutations in established and recently described resistance-associated genes, novel mutations...
Paper Details
Title
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
Published Date
Jan 22, 2018
Journal
Volume
50
Issue
2
Pages
307 - 316
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