Controlled release of FGF-2 and BMP-2 in tissue engineered periosteum promotes bone repair in rats

The aim of this study was to prepare chitosan–collagen (CS/COL) scaffolds that could release fibroblast growth factor-2 (FGF-2) and bone morphogenetic protein 2 (BMP-2), and to study the effect of this scaffold on bone repair. By improving the double emulsion/solvent evaporation technique, BMP-2 was encapsulated in poly(lactic acid)–poly(ethylene glycol)–poly(lactic acid) (PELA) microcapsules, to the surface of which FGF-2 was attached. The...