Matrices and Dermal Substitutes for Wound Treatment

Published on Jan 12, 2018
· DOI :10.1007/978-3-319-66990-8_13
Sumanas W. Jordan20
Estimated H-index: 20
(NU: Northwestern University),
Sergey Y. Turin10
Estimated H-index: 10
(NU: Northwestern University)
+ 1 AuthorsRobert D. Galiano45
Estimated H-index: 45
(NU: Northwestern University)
Sources
Abstract
Advanced wound matrices are important adjuncts to standard wound care and surgery. An understanding of their mechanisms of action leads to rational device selection for difficult wounds. We discuss the various types of advanced biofunctional wound care products currently available for wound treatment and dermal reconstruction and their most commonly used applications. Prototypic products within the categories of dermal allografts, dermal regenerative scaffolds, cellular substrates, and decellularized ECM-based materials are discussed. Dermal regenerative scaffolds are useful for temporary wound coverage to quell inflammation and prevent desiccation and infection in acute burn injury and have been used increasingly for dermal reconstruction. Cellular products and decellularized tissue matrices contain bioactive compounds that augment or stimulate wound healing pathways known to be impaired in diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs). Early DFU and VLU healing within the first 4 weeks of standard wound care can predict a need for adjunctive measures. Current data is culled from numerous randomized controlled trials and systematic reviews. Available evidence demonstrates that in the appropriate setting, biofunctional wound matrices increase rates of complete wound closure and accelerate the rate of healing.
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