Effect of PI3K/Akt signal pathway inhibitor on docetaxel nanoparticles in cell uptake, cell colony, caspase-3 & caspase-9 expression and pharmacokinetics
Volume: 44, Pages: 298 - 304
Published: Apr 1, 2018
Abstract
Docetaxel (DTX) is one kind of well-known anticancer drugs against tumors. GDC0941 was used to inhibit PI3K/Akt signal pathway and improve anti-tumor activity. PLGA-PEG-R7 (poly lactic-co-glycolic acid polyethylene glycol bending with cell penetrating peptide R7)/poly sulfadimethoxine-Folate nanoparticles (R7/PSD-Fol NPs) were made to load DTX and GDC0941 simultaneously. In vitro, the release capacity of DTX and GDC0941 inside nanoparticles was...
Paper Details
Title
Effect of PI3K/Akt signal pathway inhibitor on docetaxel nanoparticles in cell uptake, cell colony, caspase-3 & caspase-9 expression and pharmacokinetics
Published Date
Apr 1, 2018
Volume
44
Pages
298 - 304
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