Transglutaminase mediated PEGylation of nanobodies for targeted nano-drug delivery

Volume: 6, Issue: 7, Pages: 1011 - 1017
Published: Jan 1, 2018
Abstract
Targeted delivery of anticancer drugs that selectively accumulate in malignant cells could enhance drug efficacy and reduce side effects of conventional chemotherapy. In this work, we designed a single domain antibody (nanobody) based drug delivery system for targeted delivery of anticancer drugs. An anti-EGFR nanobody (Nb) was constructed with a C3-tag and a Q-tag for site specific modifications under physiological conditions. The site specific...
Paper Details
Title
Transglutaminase mediated PEGylation of nanobodies for targeted nano-drug delivery
Published Date
Jan 1, 2018
Volume
6
Issue
7
Pages
1011 - 1017
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