Transglutaminase mediated PEGylation of nanobodies for targeted nano-drug delivery
Abstract
Targeted delivery of anticancer drugs that selectively accumulate in malignant cells could enhance drug efficacy and reduce side effects of conventional chemotherapy. In this work, we designed a single domain antibody (nanobody) based drug delivery system for targeted delivery of anticancer drugs. An anti-EGFR nanobody (Nb) was constructed with a C3-tag and a Q-tag for site specific modifications under physiological conditions. The site specific...
Paper Details
Title
Transglutaminase mediated PEGylation of nanobodies for targeted nano-drug delivery
Published Date
Jan 1, 2018
Volume
6
Issue
7
Pages
1011 - 1017
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