Identification of a Pyranocoumarin Photosensitizer that is a Potent Inhibitor of Keratinocyte Growth

Photosensitizers are used in the treatment of epidermal proliferation and differentiation disorders such as psoriasis and vitiligo. In these studies, a ring‐expanded carbon homolog of the linear psoralen (furo[3,2‐g]benzopyran‐7‐one) class of photosensitizers, 4,10‐dimethyl‐ 2H,8H ‐benzo[1,2‐ b :5,4‐ b′ ]dipyran‐2‐one (NDH2476), was synthesized and analyzed for biological activity. Following activation by ultraviolet light (UVA, 320‐400 nm),...