A candidate functional SNP rs7074440 inTCF7L2alters gene expression through C-FOS in hepatocytes

The SNP rs7903146 at the transcription factor 7‐like 2 ( TCF 7L2) locus is established as the strongest known genetic marker for type 2 diabetes via genome‐wide association studies. However, the functional SNP s regulating TCF 7L2 expression remain unclear. Here, we show that the SNP rs7074440 is a candidate functional SNP highly linked with rs7903146. A reporter plasmid with rs7074440 normal allele sequence exhibited 15‐fold higher luciferase...