Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials
Abstract
Tissues stiffen during aging and during the pathological progression of cancer, fibrosis, and cardiovascular disease. Extracellular matrix stiffness is emerging as a prominent mechanical cue that precedes disease and drives its progression by altering cellular behaviors. Targeting extracellular matrix mechanics, by preventing or reversing tissue stiffening or interrupting the cellular response, is a therapeutic approach with clinical potential....
Paper Details
Title
Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials
Published Date
Jan 3, 2018
Volume
10
Issue
422
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