Injectable and body temperature sensitive hydrogels based on chitosan and hyaluronic acid for pH sensitive drug release
Abstract
Hydrogels based on chitosan/hyaluronic acid/β-sodium glycerophosphate demonstrate injectability, body temperature sensitivity, pH sensitive drug release and adhesion to cancer cell. The drug (doxorubicin) loaded hydrogel precursor solutions are injectable and turn to hydrogels when the temperature is increased to body temperature. The acidic condition (pH 4.00) can trigger the release of drug and the cancer cell (Hela) can adhere to the surface...
Paper Details
Title
Injectable and body temperature sensitive hydrogels based on chitosan and hyaluronic acid for pH sensitive drug release
Published Date
Apr 1, 2018
Journal
Volume
186
Pages
82 - 90
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