Enhanced YAP expression leads to EGFR TKI resistance in lung adenocarcinomas
Abstract
Epidermal growth factor receptor (EGFR) mutation is prevalently expressed in lung adenocarcinoma cases and acts as one of the major driving oncogenes. EGFR tyrosine kinase inhibitors (TKIs) have been used in patients with EGFR-mutant as an effective targeted therapy in lung adenocarcinoma, but drug resistance and tumor recurrence inevitably occurs. Recently, Yes-associate protein (YAP) has been reported to promote multiple cancer cell...
Paper Details
Title
Enhanced YAP expression leads to EGFR TKI resistance in lung adenocarcinomas
Published Date
Jan 10, 2018
Journal
Volume
8
Issue
1
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