Morin, a novel liver X receptor α/β dual antagonist, has potent therapeutic efficacy for nonalcoholic fatty liver diseases

Background and Purpose Morin is a natural occurring flavonoid in many dietary plants and has a wide range of beneficial effects on metabolism; however, the mechanism underlying its action remains elusive. Experimental Approach A reporter assay and the time‐resolved FRET assay were used to identify morin as a dual antagonist of liver X receptor (LXR)‐α and ‐β. Morin (100 mg . 100 g ‐1 diet) was administered to high‐fat diet‐induced obese or LXRβ...