Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering
Abstract
High-density mesenchymal stem cell (MSC) aggregates can be guided to form bone-like tissue via endochondral ossification in vitro when culture media is supplemented with proteins, such as growth factors (GFs), to first guide the formation of a cartilage template, followed by culture with hypertrophic factors. Recent reports have recapitulated these results through the controlled spatiotemporal delivery of chondrogenic transforming growth...
Paper Details
Title
Dual non-viral gene delivery from microparticles within 3D high-density stem cell constructs for enhanced bone tissue engineering
Published Date
Apr 1, 2018
Journal
Volume
161
Pages
240 - 255
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