Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis.

Volume: 416, Issue: 416, Pages: 124 - 137
Published: Mar 1, 2018
Abstract
Ferroptosis is a form of oxidative cell death and has become a chemotherapeutic target for cancer treatment. BAY 11-7085 (BAY), which is a well-known IκBα inhibitor, suppressed viability in cancer cells via induction of ferroptotic death in an NF-κB-independent manner. Reactive oxygen species scavenging, relief of lipid peroxidation, replenishment of glutathione and thiol-containing agents, as well as iron chelation, rescued BAY-induced cell...
Paper Details
Title
Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis.
Published Date
Mar 1, 2018
Volume
416
Issue
416
Pages
124 - 137
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