Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
Abstract
Selenoproteins are rare proteins among all kingdoms of life containing the 21st amino acid, selenocysteine. Selenocysteine resembles cysteine, differing only by the substitution of selenium for sulfur. Yet the actual advantage of selenolate- versus thiolate-based catalysis has remained enigmatic, as most of the known selenoproteins also exist as cysteine-containing homologs. Here, we demonstrate that selenolate-based catalysis of the essential...
Paper Details
Title
Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
Published Date
Jan 1, 2018
Journal
Volume
172
Issue
3
Pages
409 - 422.e21
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Notes
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