Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse
Abstract
Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha (TNF-α) converting enzyme, which is the molecule responsible for the release of TNF-α. In this study, Rhbdf2 knockout (KO) mice were produced by CRISPR/CAS9. To see the effects of the failure of TNF-α release induced by Rhbdf2 gene...
Paper Details
Title
Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse
Published Date
May 1, 2018
Journal
Volume
26
Issue
3
Pages
298 - 305
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