Adapting to insulin resistance in obesity: role of insulin secretion and clearance
Abstract
The aim of this study was to quantify the relative contributions of increased insulin secretion rate (ISR) and decreased insulin clearance rate (ICR) in the compensatory hyperinsulinaemia characteristic of insulin-resistant individuals without diabetes. Obese (BMI ≥30 kg/m2) individuals without diabetes (n = 91) were identified from a registry of volunteers. Volunteers underwent the following measurements: oral glucose tolerance; insulin...
Paper Details
Title
Adapting to insulin resistance in obesity: role of insulin secretion and clearance
Published Date
Dec 1, 2017
Journal
Volume
61
Issue
3
Pages
681 - 687
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