IL‐1 and IL‐1 regulatory pathways in cancer progression and therapy

Summary Inflammation is an important component of the tumor microenvironment. IL ‐1 is an inflammatory cytokine which plays a key role in carcinogenesis and tumor progression. IL ‐1 is subject to regulation by components of the IL ‐1 and IL ‐1 receptor ( ILR ) families. Negative regulators include a decoy receptor ( IL ‐1R2), receptor antagonists ( IL ‐1Ra), IL ‐1R8, and anti‐inflammatory IL ‐37. IL ‐1 acts at different levels in tumor...