Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice
Abstract
Intestinal bacteria are known to regulate bile acid (BA) homeostasis via intestinal biotransformation of BAs and stimulation of the expression of fibroblast growth factor 19 through intestinal nuclear farnesoid X receptor (FXR). On the other hand, BAs directly regulate the gut microbiota with their strong antimicrobial activities. It remains unclear, however, how mammalian BAs cross-talk with gut microbiome and shape microbial composition in a...
Paper Details
Title
Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice
Published Date
Dec 1, 2017
Journal
Volume
15
Issue
1
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