Electrospun Sandwich‐Structure Composite Membranes for Wound Dressing Scaffolds with High Antioxidant and Antibacterial Activity

Published on Feb 1, 2018in Macromolecular Materials and Engineering3.853
· DOI :10.1002/MAME.201700270
Li Jinzhen4
Estimated H-index: 4
(SCAU: South China Agricultural University),
Yang Hu21
Estimated H-index: 21
(SCAU: South China Agricultural University)
+ 8 AuthorsWuyi Zhou19
Estimated H-index: 19
(SCAU: South China Agricultural University)
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Bacterial cellulose (BC) produced by some bacteria, among them Gluconacetobacter xylinum, which secrets an abundant 3D networks fibrils, represents an interesting emerging biocompatible nanomaterial. Since its discovery BC has shown tremendous potential in a wide range of biomedical applications, such as artificial skin, artificial blood vessels and microvessels, wound dressing, among others. BC can be easily manipulated to improve its properties and/or functionalities resulting in several BC ba...
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#1Zhixin Tai (UOW: University of Wollongong)H-Index: 24
#2Yajie Liu (UOW: University of Wollongong)H-Index: 16
Last. Shi Xue Dou (UOW: University of Wollongong)H-Index: 133
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Abstract Bandaging, which has been used either to support a medical device such as a dressing or splint, or on its own to provide support to the body or restrict the motion of a part of the body, is further studied in our work in the form of multifunctional materials for self-monitoring and self-correcting by integration with carbon nanotubes (CNTs). Here, modified polymer fibers for bandages can be fabricated from fibers of commercially available bandages with carbon nanotubes uniformly adherin...
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#1Masumeh Safdari (Kermanshah University of Medical Sciences)H-Index: 1
#2Ebrahim Shakiba (Kermanshah University of Medical Sciences)H-Index: 12
Last. Ali Fattahi (Kermanshah University of Medical Sciences)H-Index: 17
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Fabrication of Ceftazidime (CTZ) loaded silk fibroin/gelatin (SF/GT) nanofibers (NFs) without the loss of structure and bioactivity of CTZ was demonstrated by electrospinning method. The structure, morphology and mechanical properties of the electrospun SF/GT nanofibrous mats were characterized using FT-IR, SEM and DSC. The drug release profile of different electrospun fibers was analyzed using spectrophotometric method, and also diffusion method was applied to assess the antibacterial effect of...
31 CitationsSource
#1Malihe-Sadat Poormasjedi-Meibod (UBC: University of British Columbia)H-Index: 9
#2Mohammadreza Pakyari (UBC: University of British Columbia)H-Index: 6
Last. Aziz Ghahary (UBC: University of British Columbia)H-Index: 57
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Dermal fibrosis, characterized by excessive extracellular matrix (ECM), is a pathological condition with limited effective therapeutic modalities. Lack of an antiscarring dressing further impedes the preventive measures for this condition. Here, we develop a new antiscarring dressing and investigate its potential as a slow-releasing vehicle for kynurenic acid (KynA), an antifibrotic agent. KynA was incorporated into polymethyl methacrylate (PMMA) nanofibers, containing increasing concentration o...
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#1Ting He (SCAU: South China Agricultural University)H-Index: 33
#1Ting He (SCAU: South China Agricultural University)H-Index: 1
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Abstract The aim of this study was to synthesis drug-loaded fibrous membrane scaffolds for potential applications as wound dressing. Polyvinylidene fluoride (PVDF) fibrous membranes were loaded with enrofloxacin (Enro) drugs by using an electrospinning process, and their mechanical strength, drug release profile and anti-bacterial properties were evaluated. Enro drug-loaded PVDF membranes exhibited good elasticity, flexibility and excellent mechanical strength. The electrospinning Enro/PVDF memb...
52 CitationsSource
#1Mehrdad Khamforoush (UKH: University of Kurdistan Hewler)H-Index: 13
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Abstract Conventional ultrafiltration (UF) membranes, which are fabricated by phase inversion method, have relatively low amount of flux rate. To overcome this limitation, a new type of thin film composite (TFC) membrane was manufactured and tested in the current study. This membrane has composed of a nonwoven Polyester (PET) support, an electrospun polyacrylonitrile (PAN) nanofibrous mid-layer, and a Polysulfone (PSF) composite coating top layer. In order to investigate the reliability of the T...
17 CitationsSource
#1Patrícia I. Morgado (NOVA: Universidade Nova de Lisboa)H-Index: 8
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Last. Ana Aguiar-Ricardo (NOVA: Universidade Nova de Lisboa)H-Index: 27
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Abstract Asymmetrical membranes have been reported as ideal wound dressings for skin regeneration. The usual methods (dry/wet-phase inversion) to produce those specific membranes are time consuming, and in majority of the cases demand the use of harmful organic solvents. In this study, supercritical carbon dioxide (scCO 2 )-assisted phase inversion method was applied to prepare poly(vinyl alcohol)/chitosan (PVA/CS) asymmetrical membranes. This technique can tailor the final structure of the dres...
70 CitationsSource
#1Fenghua Xu (UTPA: University of Texas–Pan American)H-Index: 16
#2Baicheng Weng (UTPA: University of Texas–Pan American)H-Index: 17
Last. Karen Lozano (UTPA: University of Texas–Pan American)H-Index: 32
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In this study, chitosan/polyvinyl alcohol binary and tannic acid/chitosan/polyvinyl alcohol ternary composite nanofiber membranes from chitosan citric acid salt aqueous solutions without the use of toxic solvents through Forcespinning® technology were successfully mass produced. Chitosan is being widely evaluated as a wound dressing material based on its biocompatibility, biodegradability, and antibacterial properties. Tannic acid has been applied as a drug for the treatment of wounds due to its...
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#1Xiuli Hu (CAS: Chinese Academy of Sciences)H-Index: 28
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Last. Xiabin Jing (CAS: Chinese Academy of Sciences)H-Index: 102
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Abstract Electrospinning has been recognized as a simple and versatile method for fabrication of polymer nanofibers. Various polymers that include synthetic, natural, and hybrid materials have been successfully electrospun into ultrafine fibers. The inherently high surface to volume ratio of electrospun fibers can enhance cell attachment, drug loading, and mass transfer properties. Drugs ranging from antibiotics and anticancer agents to proteins, DNA, RNA, living cells, and various growth factor...
671 CitationsSource
#1Anna K. Blakney (UW: University of Washington)H-Index: 17
#2Emily Krogstad (UW: University of Washington)H-Index: 7
Last. Kim A. Woodrow (UW: University of Washington)H-Index: 19
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BACKGROUND: Electrospun drug-eluting fabrics have enormous potential for the delivery of physicochemically diverse drugs in combination by controlling the underlying material chemistry and fabric microarchitecture. However the rationale for formulating drugs at high drug loading in the same or separate fibers is unknown but has important implications for product development and clinical applications. METHODS: Using a production-scale free-surface electrospinning instrument we produced electrospu...
49 CitationsSource
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#1Cláudia Mouro (UBI: University of Beira Interior)H-Index: 5
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#1Bahareh AzimiH-Index: 8
#2Homa Maleki (University of Birjand)H-Index: 8
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Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the natural wound healing process may be ineffective or insufficient, leading to detrimental and painful conditions that require repair adjuvants and tissue substitutes. In addition to the conventional wound care options, biodegradable polymers, both sy...
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#1Mehmet Evren Okur (UHSA: University of Health Sciences Antigua)H-Index: 10
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Abstract Wound healing is an unmet therapeutic challenge among medical society since wound assessment and management is a complex procedure including several factors playing major role in healing process. Wounds can mainly be categorized as acute or chronic. It is well referred that the acute wound displays normal wound physiology while healing, in most cases, is seemed to progress through the normal phases of wound healing. On the other hand, a chronic wound is physiologically impaired. The mai...
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Polimerik elektroegirme lifler, yara iyilesme uygulamalari icin iyi tasarimli iskeleler sunmaktadir. Burada, kurkumin (Cur) iceren biyobazli poliuretan (PU) karisim liflerin uretimi rapor edilmektedir. Y alnizca polimer konsantrasyonu degil, ayni zamanda kurkumin konsantrasyonu, fiberlerin morfolojisi, capi ve temas acisi degerlerini etkilemistir. Morfolojik arastirmalar, PU liflerinin capinin ve hidrofilikliginin kurkumin ilavesi uzerine arttigini ortaya koymustur. Proses parametrelerinin (uygu...
#1Danilo A. Locilento (UFSCar: Federal University of São Carlos)H-Index: 3
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The development of nanofibrous membranes with tunable wettability, degradation, and biocompatibility is highly keen for biomedical applications, including drug delivery and wound dressing. In this study, biocompatible and biodegradable nanofibrous membranes with antioxidant properties were successfully prepared by the electrospinning technique. The membranes were developed using polylactic acid (PLA) and polyethylene oxide (PEO) as the matrix, with the addition of grape seed extract (GSE), a ric...
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#1Dilayda Kanmaz (Yalova University)H-Index: 1
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