Electrospun Sandwich‐Structure Composite Membranes for Wound Dressing Scaffolds with High Antioxidant and Antibacterial Activity

Published on Feb 1, 2018in Macromolecular Materials and Engineering3.853
· DOI :10.1002/MAME.201700270
Li Jinzhen4
Estimated H-index: 4
(SCAU: South China Agricultural University),
Yang Hu21
Estimated H-index: 21
(SCAU: South China Agricultural University)
+ 8 AuthorsWuyi Zhou19
Estimated H-index: 19
(SCAU: South China Agricultural University)
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Abstract
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Abstract Bandaging, which has been used either to support a medical device such as a dressing or splint, or on its own to provide support to the body or restrict the motion of a part of the body, is further studied in our work in the form of multifunctional materials for self-monitoring and self-correcting by integration with carbon nanotubes (CNTs). Here, modified polymer fibers for bandages can be fabricated from fibers of commercially available bandages with carbon nanotubes uniformly adherin...
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Fabrication of Ceftazidime (CTZ) loaded silk fibroin/gelatin (SF/GT) nanofibers (NFs) without the loss of structure and bioactivity of CTZ was demonstrated by electrospinning method. The structure, morphology and mechanical properties of the electrospun SF/GT nanofibrous mats were characterized using FT-IR, SEM and DSC. The drug release profile of different electrospun fibers was analyzed using spectrophotometric method, and also diffusion method was applied to assess the antibacterial effect of...
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Dermal fibrosis, characterized by excessive extracellular matrix (ECM), is a pathological condition with limited effective therapeutic modalities. Lack of an antiscarring dressing further impedes the preventive measures for this condition. Here, we develop a new antiscarring dressing and investigate its potential as a slow-releasing vehicle for kynurenic acid (KynA), an antifibrotic agent. KynA was incorporated into polymethyl methacrylate (PMMA) nanofibers, containing increasing concentration o...
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Abstract The aim of this study was to synthesis drug-loaded fibrous membrane scaffolds for potential applications as wound dressing. Polyvinylidene fluoride (PVDF) fibrous membranes were loaded with enrofloxacin (Enro) drugs by using an electrospinning process, and their mechanical strength, drug release profile and anti-bacterial properties were evaluated. Enro drug-loaded PVDF membranes exhibited good elasticity, flexibility and excellent mechanical strength. The electrospinning Enro/PVDF memb...
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Abstract Asymmetrical membranes have been reported as ideal wound dressings for skin regeneration. The usual methods (dry/wet-phase inversion) to produce those specific membranes are time consuming, and in majority of the cases demand the use of harmful organic solvents. In this study, supercritical carbon dioxide (scCO 2 )-assisted phase inversion method was applied to prepare poly(vinyl alcohol)/chitosan (PVA/CS) asymmetrical membranes. This technique can tailor the final structure of the dres...
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In this study, chitosan/polyvinyl alcohol binary and tannic acid/chitosan/polyvinyl alcohol ternary composite nanofiber membranes from chitosan citric acid salt aqueous solutions without the use of toxic solvents through Forcespinning® technology were successfully mass produced. Chitosan is being widely evaluated as a wound dressing material based on its biocompatibility, biodegradability, and antibacterial properties. Tannic acid has been applied as a drug for the treatment of wounds due to its...
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Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the natural wound healing process may be ineffective or insufficient, leading to detrimental and painful conditions that require repair adjuvants and tissue substitutes. In addition to the conventional wound care options, biodegradable polymers, both sy...
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