Tissue source determines the differentiation potentials of mesenchymal stem cells: a comparative study of human mesenchymal stem cells from bone marrow and adipose tissue.

Published on Dec 6, 2017in Stem Cell Research & Therapy6.832
路 DOI :10.1186/S13287-017-0716-X
Liangliang Xu24
Estimated H-index: 24
(Guangzhou University of Chinese Medicine),
Yamei Liu10
Estimated H-index: 10
(GU: Guangzhou University)
+ 7 AuthorsGang Li81
Estimated H-index: 81
Sources
Abstract
Background Mesenchymal stem cells (MSCs) possess intrinsic regeneration capacity as part of the repair process in response to injury, such as fracture or other tissue injury. Bone marrow and adipose tissue are the major sources of MSCs. However, which cell type is more effective and suitable for cell therapy remains to be answered. The intrinsic molecular mechanism supporting the assertion has also been lacking.
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#1Weiping Lin (CUHK: The Chinese University of Hong Kong)H-Index: 10
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Summary Cell therapy continues to attract growing interest as a promising approach to treat a variety of diseases. Mesenchymal stem cells (MSCs) have been one of the most intensely studied candidates for cell therapy. Since the homing capacity of MSCs is an important determinant of effective MSC-based therapy, the enhancement of homing efficiency is essential for optimizing the therapeutic outcome. Furthermore, trafficking of endogenous MSCs to damaged tissues, also referred to as endogenic stem...
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Mesenchymal stem cells (MSCs) are immune privileged and a cell source for tissue repair. Previous studies showed that there is systemic mobilization of osteoblastic precursors to the fracture site. We hypothesized that both systemic and local administration of allogeneic MSCs may promote fracture healing. Bone marrow-derived MSCs and skin fibroblasts were isolated from GFP Sprague鈥揇awley rats, cultured, and characterized. Closed transverse femoral fracture with internal fixation was established ...
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#3Rui Chen (CUHK: The Chinese University of Hong Kong)H-Index: 31
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#1Young-Dan Cho (SNU: Seoul National University)H-Index: 13
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#1Martin J. Hoogduijn (EUR: Erasmus University Rotterdam)H-Index: 57
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Mesenchymal stem cells (MSC) are emerging as a therapeutic option for a plethora of immunological and degenerative diseases. Preclinical research is focusing on the mechanisms of MSCmediated immunomodulation and regeneration. This Research Topic shines light on mechanistic and regulatory aspects that are of importance for understanding the full potential of MSC for clinical use in transplantation and tissue regeneration. A first consideration to make when studying MSC that is addressed in this R...
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