Drug-resistant epilepsy in MELAS: safety and potential efficacy of lacosamide

Mitochondrial disorders are a group of neurometabolic and neurodegenerative diseases caused by impairment of the mitochondrial respiratory chain. There is no clear evidence supporting any pharmacological interventions for the majority of mitochondrial disorders, except Leber hereditary optic neuropathy, coenzyme Q10 deficiencies, and mitochondrial neurogastrointestinal encephalomyopathy. Furthermore, some drugs may have detrimental effects on...