Adipose tissue-resident macrophages and obesity

Type 2 diabetes and insulin resistance are one of the major consequences of obesity as a result of inflammation in adipose tissues. Adipose tissue-resident macrophages (ATMs) have a primary role in tissue remodeling and maintenance of homeostasis within adipose tissue. Two different types of macrophages are present in adipose tissue i.e. M1 and M2-type. Obesity is associated phenotypic transformation of macrophages, from anti-inflammatory M2 to...