Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies
Abstract
Most neurodegenerative diseases are proteinopathies, which are characterized by the aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to aggregate, particularly when cellular clearance systems start to fail in the context of ageing, only a few form fibrillar aggregates. In Alzheimer disease, the peptide amyloid-β (Aβ) and the protein tau aggregate to form plaques and tangles, respectively, which comprise the...
Paper Details
Title
Amyloid-β and tau complexity — towards improved biomarkers and targeted therapies
Published Date
Dec 15, 2017
Journal
Volume
14
Issue
1
Pages
22 - 39
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Notes
History