Cell cycle regulation and anticancer drug discovery

Volume: 14, Issue: 4, Pages: 348 - 362
Published: Nov 15, 2017
Abstract
Cellular growth, development, and differentiation are tightly controlled by a conserved biological mechanism: the cell cycle. This cycle is primarily regulated by cyclin-dependent kinase (CDK)-cyclin complexes, checkpoint kinases, and CDK inhibitors. Deregulation of the cell cycle is a hallmark of the transformation of normal cells into tumor cells. Given its importance in tumorigenesis, several cell cycle inhibitors have emerged as potential...
Paper Details
Title
Cell cycle regulation and anticancer drug discovery
Published Date
Nov 15, 2017
Volume
14
Issue
4
Pages
348 - 362
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