Epigenome in Early Mammalian Development: Inheritance, Reprogramming and Establishment
Abstract
Drastic epigenetic reprogramming takes place during preimplantation development, leading to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in remodeling of the epigenomes can cause severe developmental defects, including embryonic lethality. However, how chromatin modifications and chromatin organization are reprogrammed upon fertilization in mammals has long remained elusive. Here, we review recent...
Paper Details
Title
Epigenome in Early Mammalian Development: Inheritance, Reprogramming and Establishment
Published Date
Mar 1, 2018
Journal
Volume
28
Issue
3
Pages
237 - 253
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