A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection
Abstract
Detection of extracellular vesicle (EV)-associated RNAs with low expression levels in early-stage cancer remains a challenge and is highly valuable. Here, we report a nanoparticle-based biochip that could capture circulating EVs without isolation, brighten encapsulated RNAs, and amplify fluorescence signals in situ in a single step. We confine catalyzed hairpin DNA circuit (CHDC) in cationic lipid-polymer hybrid nanoparticles (LPHNs) that are...
Paper Details
Title
A signal-amplifiable biochip quantifies extracellular vesicle-associated RNAs for early cancer detection
Published Date
Nov 22, 2017
Journal
Volume
8
Issue
1
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