International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma

Target delineation in nasopharyngeal carcinoma (NPC) often proves challenging because of the notoriously narrow therapeutic margin. High doses are needed to achieve optimal levels of tumour control, and dosimetric inadequacy remains one of the most important independent factors affecting treatment outcome.A review of the available literature addressing the natural behaviour of NPC and correlation between clinical and pathological aspects of the...