Dynamic m6A modification regulates local translation of mRNA in axons
Abstract
N6-methyladenosine (m6A) is a reversible modification in mRNA and has been shown to regulate processing, translation and decay of mRNA. However, the roles of m6A modification in neuronal development are still not known. Here, we found that the m6A eraser FTO is enriched in axons and can be locally translated. Axon-specific inhibition of FTO by rhein, or compartmentalized siRNA knockdown of Fto in axons led to increases of m6A levels. GAP-43 mRNA...
Paper Details
Title
Dynamic m6A modification regulates local translation of mRNA in axons
Published Date
Nov 23, 2017
Journal
Volume
46
Issue
3
Pages
1412 - 1423
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