Nanotechnology: A Tool for Targeted Drug Delivery

Published on Jan 1, 2017
· DOI :10.1007/978-3-319-70299-5_5
Suchitra S. Mishra1
Estimated H-index: 1
(RTMNU: Rashtrasant Tukadoji Maharaj Nagpur University),
Kunal B. Banode1
Estimated H-index: 1
(RTMNU: Rashtrasant Tukadoji Maharaj Nagpur University),
Veena S. Belgamwar23
Estimated H-index: 23
(RTMNU: Rashtrasant Tukadoji Maharaj Nagpur University)
Sources
Abstract
Nanotechnology has the potential to revolutionize diagnosis and therapy. Advances in protein engineering and material science have contributed to novel nanoscale targeting approaches that may bring new hope to patients. Recent developments in nanotechnology offer opportunities to significantly transform therapeutics. This technology has enabled the manipulation of the biological and physicochemical properties of nanomaterials to facilitate more efficient target-specific drug therapy. Engineered nanoparticles are an important tool to realize a number of these applications. Generally, particles having size ≤100 nm can only be used for medical purpose. Recent years have witnessed unprecedented growth of research and applications in the area of nanoscience and nanotechnology. There is an increasing optimism that nanotechnology, as applied to medicine, will bring significant advances in the diagnosis and treatment of disease.
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References27
Newest
#1Saurabh BhatiaH-Index: 13
Source
Nanotechnologyis the study of extremely small structures, having size of 0.1 to 100 nm. Nano medicine is a relatively new field of science and technology. Brief explanation of various types of pharmaceutical nano systems is given. Classification of nano materials based on their dimensions is given. An application of Nanotechnology in various fields such as health and medicine, electronics, energy and environment, is discussed in detail. Applications of nano particles in drug delivery, protein an...
Source
#1A.P. GadadH-Index: 1
#2Vijay Kumar S MH-Index: 1
Last. N. Pavani PallaviH-Index: 1
view all 5 authors...
Source
#1Bhatt NehaH-Index: 2
#2Bhatt GaneshH-Index: 2
Last. Kothiyal PreetiH-Index: 2
view all 3 authors...
Nanoparticle drug carriers consist of solid biodegradable particles in size ranging from 10 to 1000 nm (50–300 nm generally). The use of minute particles as drug carriers for targeted treatment has been studied over a long period of time. A selective accumulation of active substances in target tissues has been demonstrated for certain so-called nanocarrier systems that are administered bound to pharmaceutical drugs. Great expectations are placed on nanocarrier systems that can overcome natural b...
Source
Aims: The present study reports a novel approach for enhancing the oral absorption and hypoglycemic activity of insulin via encapsulation in folate-(FA) coupled polyethylene glycol (PEG)ylated polylactide-coglycolide (PLGA) nanoparticles (NPs; FA-PEG-PLGA NPs). Materials & methods: Insulin-loaded FA-PEG-PLGA NPs (size ~260 nm; insulin loading ~6.5% [w/w]; encapsulation efficiency: 87.0 ± 1.92%) were prepared by double-emulsion solvent evaporation method. The bioavailability and hypoglycemic acti...
Source
#1Shaker A. Mousa (Albany College of Pharmacy and Health Sciences)H-Index: 66
#2Dhruba J. Bharali (Albany College of Pharmacy and Health Sciences)H-Index: 28
The application of nanotechnology to biomedicine, particularly in cancer diagnosis and treatment, promises to have a profound impact on healthcare. The exploitation of the unique properties of nano-sized particles for cancer therapeutics is most popularly known as nanomedicine. The goals of this review are to discuss the current state of nanomedicine in the field of cancer detection and the subsequent application of nanotechnology to treatment. Current cancer detection methods rely on the patien...
Source
#1Robby A. Petros (UNT: University of North Texas)H-Index: 10
#2Joseph M. DeSimone (UNC: University of North Carolina at Chapel Hill)H-Index: 101
Advances in nanoparticle engineering, and in understanding of the importance of nanoparticle characteristics such as size, shape and surface properties for biological interactions, are creating new opportunities for the development of nanoparticles for therapeutic applications such as targeted drug delivery. Petros and DeSimone review the impact of nanoparticle characteristics on their biological properties and recent progress in the rational design of nanoparticle therapeutics, discussing the c...
Source
#1Yanzhen Li (Sichuan University)H-Index: 3
#2Xun Sun (Sichuan University)H-Index: 55
Last. Zhirong Zhang (Sichuan University)H-Index: 67
view all 6 authors...
Purpose Microparticles containing solid lipid nanoparticles (SLNs) are receiving increased attention as carriers for the lung delivery of the SLNs. Thus, we aim to prepare the hybrid microparticles and thoroughly evaluate their feasibility for the pulmonary drug delivery.
Source
Ceramic/polymer composites have been considered as third-generation orthopedic biomaterials due to their ability to closely match properties (such as surface, chemistry, biological, and mechanical) of natural bone. It has already been shown that the addition of nanophase compared with conventional (or micron-scale) ceramics to polymers enhances bone cell functions. However, in order to fully take advantage of the promising nanometer size effects that nanoceramics can provide when added to polyme...
Source
#1Xu Wang (Emory University)H-Index: 23
#2Lily Yang (Emory University)H-Index: 44
Last. Dong M. Shin (Emory University)H-Index: 87
view all 4 authors...
Recent developments in nanotechnology have provided researchers with new tools for cancer imaging and treatment. This technology has enabled the development of nanoscale devices that can be conjugated with several functional molecules simultaneously, including tumor-specific ligands, antibodies, anticancer drugs, and imaging probes. Since these nanodevices are 100 to 1,000-fold smaller than cancer cells, they can be easily transferred through leaky blood vessels and interact with targeted tumor-...
Source
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#1J. Genova (BAS: Bulgarian Academy of Sciences)H-Index: 10
#2Hassan Chamati (BAS: Bulgarian Academy of Sciences)H-Index: 11
Last. Minko Petrov (BAS: Bulgarian Academy of Sciences)H-Index: 14
view all 3 authors...
Abstract Using two typical experimental methods, differential scanning calorimetric (DSC) analysis and Fourier Transform Infrared (FTIR) spectroscopy, we have studied the effect of single wall carbon nanotubes (SWCNTs), both amide functionalized (f–SWCNTs) and non-functionalized pristine (p-SWCNTs), on the thermal and structural properties of the SOPC phospholipid. We proposed and discussed possible physical mechanisms driving the thermodynamic and structural states of the bionanocomposites – SO...
Source
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