Review paper

The PDGF/PDGFR pathway as a drug target

Volume: 62, Pages: 75 - 88
Published: Aug 1, 2018
Abstract
Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration, primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed in a wide array of pathological conditions, such as cancer, fibrosis, neurological conditions and atherosclerosis. Reported abnormalities of the PDGF pathway include overexpression or amplification of PDGF receptors (PDGFRs), gain of function point mutations or...
Paper Details
Title
The PDGF/PDGFR pathway as a drug target
Published Date
Aug 1, 2018
Volume
62
Pages
75 - 88
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