Investigation of Sub-Centimeter Lung Nodule Quantification for Low-Dose PET

With the recent development of high resolution time-of-flight (TOF) positron emission tomography (PET) and resolution recovery incorporated in the reconstruction algorithm, accurate detection, and quantification of sub-centimeter nodules might become feasible. In this paper, we performed a comprehensive simulation and mini-Derenzo phantom study to explore the quantitative accuracy of sub-centimeter nodules using the Siemens Biograph mCT scanner....