Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling
Abstract
The mammary epithelium comprises two primary cellular lineages, but the degree of heterogeneity within these compartments and their lineage relationships during development remain an open question. Here we report single-cell RNA profiling of mouse mammary epithelial cells spanning four developmental stages in the post-natal gland. Notably, the epithelium undergoes a large-scale shift in gene expression from a relatively homogeneous basal-like...
Paper Details
Title
Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling
Published Date
Nov 20, 2017
Journal
Volume
8
Issue
1
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