The role of CYP17A1 in prostate cancer development: structure, function, mechanism of action, genetic variations and its inhibition

Volume: 36, Issue: 05, Pages: 487 - 499
Published: Jan 1, 2017
Abstract
Androgens play an important role during the development of both normal prostate epithelium and prostate cancer and variants of genes involved in androgen metabolism may be related to an increased risk of prostate disease. Cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1) is a key regulatory enzyme in the steroidogenic pathway; it catalyses both 17α-hydroxylase and 17,20-lyase activities and is essential for the production of both androgens...
Paper Details
Title
The role of CYP17A1 in prostate cancer development: structure, function, mechanism of action, genetic variations and its inhibition
Published Date
Jan 1, 2017
Volume
36
Issue
05
Pages
487 - 499
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