Neuroglobin Overexpression Promotes Mitochondrial Fusion and Prevents Mitochondrial Network Fragmentation in SHSY5Y Cells Subjected to Pro-apoptotic Conditions

Oxidative stress and hypoxia play a central role in neuronal injury and cell death in acute and chronic pathological conditions. Neuroglobin (NGB) is a monomeric heme-protein found in neurons that, when overexpressed, confers resistance to apoptosis cause by oxidative stress, hypoxia, and neurotoxicity. Although NGB has been traditionally considered a cytoplasmic protein, recent findings indicate that NGB can localize to mitochondria. However,...