A novel anti-melanogenic agent, KDZ-001, inhibits tyrosinase enzymatic activity

The demand for anti-melanogenic agents is increasing due to the unwanted side effects of current treatments. To find an effective anti-melanogenic agent, we used zebrafish as a whole animal model for phenotype-based drug and cosmetic discovery screening.The aim of this study was to identify and explore a small molecule that could be used for skin-whitening cosmetics.Using zebrafish embryos, we examined the effects of 1000 compounds on zebrafish...