Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.

Volume: 8, Issue: 1, Pages: 1758 - 1758
Published: Nov 24, 2017
Abstract
Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (SCCs). However, Notch1 can be stochastically activated to promote carcinogenesis in murine models of SCC. Activated form of Notch1 promotes xenograft tumor growth when expressed ectopically. Here, we demonstrate that Notch1 activation and...
Paper Details
Title
Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.
Published Date
Nov 24, 2017
Volume
8
Issue
1
Pages
1758 - 1758
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