Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer
Abstract
N-Methylpyrrole-N-methylimidazole (PI) polyamides are a class of DNA minor groove binders with DNA sequence-specificity. DNA-alkylating PI polyamide conjugates are attractive candidates as anticancer drugs acting through DNA damage and its subsequent inhibition of cell proliferation. One example is a chlorambucil-PI polyamide conjugate targeting the runt-related transcription factor (RUNX) family. RUNX1 has pro-oncogenic properties in acute...
Paper Details
Title
Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer
Published Date
Jan 1, 2018
Volume
26
Issue
1
Pages
1 - 7
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